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KMID : 0374919940150040655
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Inje Medical Journal
1994 Volume.15 No. 4 p.655 ~ p.660
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Serum Concentrations of Salicylates with Kawasaki Disease
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Abstract
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In kawasaki disease, many studies have reported about risk factiors of coronary artery involvement. This study was designed to evaluate factors influencing coronary artery involvement including serum salicylate concentration of third day after
oral
aspirin )(100 mg/kg/day divided to four) administration in 93 children (involved group =21, uninvolved group =72) and to evaluate the relationships between serum salicylate concentration and gastric pH, unine pH and serum albumin concentration.
@ES The results were as follows :
@EN 1) Male children were more frequently complicated by coronary artyery disease.
2) The mean of the highest ESR during the course was 10.30 35.7 mm/hr in the involved group and 85.5 4.5mm/hr in the uninvolved group (p=0.038).
3) There was significant difference in comparison of the mean serum salicylate concentrations between involved and uninvolved group, 8.2 4.5mg/dl and 10.9 5.9 mg/dl, respectively (p=0.048).
4) There were no relationships between serum salicylate concentration and gastric pH, urine pH and serum albumin concentration.
These results suggest that the serum salicylate concentration during acute phase may be a factor influencing coronary artery involvement in Kawasakidisease.
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